๐ƒ๐จ๐ฉ๐š๐ฆ๐ข๐ง๐ž ๐š๐ง๐ ๐‹๐š๐œ๐ญ๐š๐ญ๐ข๐จ๐ง โฃ

In Australia, dopamine antagonists are antipsychotic or antiemetics (sometimes theyโ€™re both).โฃ โฃ


Look at the adverse effects for these dopamine antagonists, do you see how they list hyperprolactinaemia (high levels of prolactin in the blood)?โฃ โฃ
Now, remember, whether a medicine is giving a desired effect, or an adverse effect, is RELATIVE to the patient and their condition(s).โฃ
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We see this in the dopamine antagonists domperidone and metoclopramide. They use this mechanism of increasing prolactin to give the desired effect of lactation stimulation for breastfeeding women.โฃ
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Now let us look at dopamine agonists (most of them treat Parkinsonโ€™s disease). Youโ€™ll see in their adverse effects or breastfeeding section it says to avoid in breastfeeding as it may inhibit lactation (it does this by suppressing prolactin โ€“ the opposite of what dopamine antagonist do).โฃ โฃ


Yet once again we have medicines that utilise an adverse effect to create a desired effect. Carbergoline and bromocriptine are two dopamine agonists that a treat hyperprolactinaemia (including prolactinomas) and prevention of the onset of lactation in the puerperium for clearly defined medical reasons.โฃ
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TLDR: Dopamine antagonist = lactation stimulation. Dopamine agonist = lactation inhibition. Whether these are adverse or desired effect depends on the patient. โฃ
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